K., Alonso, E., Fang, G., Ferrara, M., Hynd, G. Catalytic asymmetric synthesis of epoxides from aldehydes using sulfur ylides with in situ generation of diazocompounds. A novel route to 2-arylcyclopropylamines. Catalytic cyclopropanation of alkenes using diazo compounds generated in situ. The use of tosylhydrazone salts as a safe alternative for handling diazo compounds and their applications in organic synthesis. Dual labeling of biomolecules by using click chemistry: a sequential approach. Click chemistry and medicinal chemistry: a case of ‘cyclo-addition’. Click chemistry: diverse chemical function from a few good reactions. Domino iron catalysis: direct aryl–alkyl cross-coupling. Green Chemistry and Catalysis (Wiley-VCH, 2007).Ĭzaplik, W. Metal-Catalyzed Cross-Coupling Reactions (Wiley-VCH, 2004). As the required tosylhydrazones are easily generated from carbonyl compounds, it can be seen as a reductive coupling of carbonyls, a process of high synthetic relevance that requires several steps using other methodologies.ĭe Mejiere, A. This reaction is very general and functional-group tolerant. Here, we report a new and efficient metal-free carbon–carbon bond-forming coupling between tosylhydrazones and boronic acids. Similarly, efficient processes that do not require a metal catalyst are of extraordinary interest. In this context, the development of new cross-coupling reactions that use catalysts based on inexpensive and non-toxic metals is attracting increasing attention. In spite of the myriad methods available, advantageous methodologies in terms of selectivity, availability of starting materials, operational simplicity, functional-group tolerance, environmental sustainability and economy are in constant demand. The formation of carbon–carbon bonds is a fundamental transformation in organic synthesis.

Bamford stevens reaction pdf